TMC Study Warns: Even Small Amounts of Alcohol Increase Mouth Cancer Risk (2025)

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TMC Study 2025: No Safe Limit for Alcohol in Mouth Cancer Risk
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A landmark study by the Tata Memorial Centre (TMC) has revealed that there is no safe limit for alcohol consumption when it comes to oral cancer. The research specifically highlights that even minimal intake, such as a few gulps of beer, significantly raises the risk of buccal mucosa cancer in India.

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No Safe Limit for Alcohol Consumption

The study, published in BMJ Global Health, indicates that even low daily intake—just 9 grams or roughly one standard drink—is linked to a 50% heightened risk of mouth cancer. Specifically, consuming just two grams of alcohol from beer daily was associated with a 59% higher risk compared to non-drinkers. Researchers emphasize that the “safe limit” is a myth, as any amount of ethanol can alter the mouth’s inner lining and increase its vulnerability to carcinogens.

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The Deadly Synergy: Alcohol and Tobacco

The findings underscore a “more than additive” danger when alcohol is combined with tobacco chewing. While tobacco alone triples the risk and alcohol alone increases it by 76%, the combination leads to a staggering 346% increased risk. This synergy accounts for 62% of all buccal mucosa cancer cases in India. Consequently, health experts are calling for urgent public awareness and stricter alcohol control policies to combat this preventable disease.

Impact of Locally Brewed Alcohol – Key Figures

Parameter Impact on Risk
Alcohol Consumption (Overall) 68% Higher Risk
Regulated Drinks (Whisky/Beer) 72% Higher Risk
Locally Brewed Liquor (Tharra/Desi) 87% Higher Risk
Joint Alcohol & Tobacco Impact 62% of Cases Attributable
5-Year Survival Rate 43%

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Risk Variation Across Indian States

The burden of alcohol-related oral cancer varies significantly across the country. In states like Meghalaya, Assam, and Madhya Pradesh, over 14% of buccal mucosa cancers are linked to alcohol. In contrast, states with alcohol bans, such as Gujarat, show a much lower attributable risk. Experts point out that unregulated local drinks often contain toxic contaminants like methanol, which further spikes mortality rates.

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Conclusion and Disclaimer

The Tata Memorial Centre study provides clear evidence that avoiding both alcohol and tobacco is the most effective way to eliminate mouth cancer. As survival rates remain poor due to late diagnosis, prevention through lifestyle changes is critical.

Disclaimer: This report summarizes medical research findings published in December 2025. Always consult a healthcare professional for personalized medical advice and screening for oral health…

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